The Lombok earthquake on August 5, 2018, which originated from the back-arc thrust zone in the northern part of Lombok Island, caused extensive damage and casualties in Mataram City, the capital of West Nusa Tenggara Province, Indonesia. Therefore, disaster mitigation is essential to anticipate the impacts of future earthquakes, for example, by constructing major public facilities in zones with lower seismic vulnerability. This research aimed to assess seismic considerations in the western part of Mataram for regional spatial planning based on amplification value, peak ground acceleration (PGA), ground shear strain, and sedimentary layer thickness. We combined these parameters using the Simple Additive Weight (SAW) method to decide the potential area of high earthquake impact / seismic vulnerability. Microtremor data from 125 points in the western part of Mataram city were processed using the Horizontal to Vertical Spectral Ratio (HVSR) and Ellipticity Curve methods. The results show that the western part of Mataram has amplification factor values ranging from 2.610 to 10.590, PGA values ranging from 23.641 to 27.225 gal, ground shear strain ranging from 0.001 to 0.004, and sediment layer thickness ranging from 19 to 47 m. Sekarbela, Ampenan, and the southern part of Mataram exhibit the highest amplification factors, seismic vulnerability indices, and ground shear strain values. The results of the Simple Additive Weighting (SAW) method further indicate that these areas fall within the high seismic vulnerability zone. Based on the Indonesian National Standard (SNI) 1726-2019 which addresses earthquake-resistant design for building and non-building structures, we recommend that only structures in Risk Categories I and II be developed in these high seismic vulnerability (SV) zones. In contrast, for Selaparang subdistrict, which fall within the medium seismic vulnerability zone, we recommend the development of buildings classified under Risk Category III.